About C4 Therapeutics:
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical
company dedicated to delivering on the promise of targeted protein degradation
science to create a new generation of medicines that transforms patients’ lives.
C4T is progressing targeted oncology programs through clinical studies and
leveraging its TORPEDO® platform to efficiently design and optimize
small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader
medicines are designed to harness the body’s natural protein recycling system to
rapidly degrade disease-causing proteins, offering the potential to overcome
drug resistance, drug undruggable targets and improve patient outcomes. For more
information, please visit www.c4therapeutics.com
[http://www.c4therapeutics.com].
Job Summary
As an Associate Medical Director, you will guide and support clinical programs,
bringing together your medical expertise, collaborative mindset, and ability to
inspire cross-functional teams. You will support the clinical development plan
for new compounds, and clinical studies, and partner with Program Teams across
Research & Development to map the path toward regulatory approval. You’ll work
closely with colleagues across all phases of development, lead discussions with
academic study investigators, engage with opinion leaders, and engage with
Health Authorities on behalf of C4T. A genuine passion for advancing science, a
talent for uniting diverse perspectives, and a shared commitment to improving
the lives of patients with cancer will be key to success in this role.
Your Role
* Drive development programs, collaborating with Program Management, Clinical
Operations, Regulatory Affairs, and cross-functional teams, collaboratively
refining oncology clinical study protocols from first-in-human Phase I
through pivotal studies supporting regulatory submissions.
* Collaborate with cross-functional teams, including clinical operations,
regulatory affairs, and biostatistics, to ensure alignment on clinical
strategy and study design.
* Serve as the medical monitor for assigned clinical trials in relapsed
refractory multiple myeloma, providing ongoing medical oversight and
guidance, addressing any issues that arise, including those related to
protocol conduct and/or individual subject safety to ensure timely completion
and high-quality data.
* Guide decision-making on recruitment, study conduct and on dose escalation
and early clinical signals of activity if appropriate to trial stage.
* Assesses overall safety information for studies and compound in conjunction
with Pharmacovigilance.
* Develop and maintain strong relationships with key opinion leaders,
investigators, and clinical trial sites.
* In collaboration with C4T’s Senior Medical Director, provide input in
preparing global regulatory filings, including clinical sections of
Investigator’s Brochures (IBs), Investigational New Drug (IND) applications,
Clinical Trial Applications (CTAs), and New Drug Applications (NDAs).
* Facilitate regular engagement with academic clinical investigators, support
site initiation visits, and lead investigator meetings in a way that fosters
collaboration, trust, and shared learning.
* Assist Pharmacovigilance in reviewing and interpreting clinical data,
ensuring accuracy, context, and patient safety.
* Serve as a representative of C4T with the scientific community, contribute to
publication plans, and build relationships with external experts to inform
program strategies.
Your Background
Required:
* A M.D., or internationally recognized equivalent, with at least one year of
clinical research experience within the pharmaceutical industry, at a CRO or
health-related consulting company, or within academia.
* A flexible contributor who can balance strategic vision with hands-on
execution and work both collaboratively in a fast-paced, team-based matrix
environment and to function independently as appropriate.
* Exceptional scientific communication skills who listens actively, adapts to
diverse audiences, and builds understanding across teams and stakeholders.
* Superior interpersonal and negotiating skills with the ability to proactively
predict issues and solve problems and drive decision-making within a
multi-disciplinary, multi-regional, matrix teams by leveraging diplomacy and
positive influencing abilities.
* Strong analytical and problem-solving skills with keen attention to detail.
Preferred:
* Clinical Development experience in biotechnology or pharmaceutical settings,
including experience with companion diagnostics, clinical operations, and
pharmacovigilance.
* Experience with oncology and/or hematology, either in practice or in a life
sciences setting
Compensation
The base pay range for this position at commencement of employment is expected
to be between $230,938.00 and $255,245.00 annually; however, base pay offered
may vary depending on multiple individualized factors, including job-related
knowledge, skills, and experience.
C4 Therapeutics is an Equal Opportunity Employer.